Humanities, Social Sciences & Thought BiologyENEP 264: What AI’s math breakthroughs mean for drug development and geneticsPatrick ShortNovember 5, 2026 41 min★ ★ ★ ★ ☆ 4/5AIGeneticsDrug Development
Life & Natural Systems Medicine & HealthENEP 263: Bringing the first cardiovascular gene editing therapy to patients with Sek KathiresanSano GeneticsOctober 29, 2026 37 min★ ★ ★ ★ ★ 5/5CardiovascularGene EditingPCSK9
Life & Natural Systems Medicine & HealthENEP 262: The genetic drivers of hemochromatosis, drug response, and multimorbidity with Luke PillingLuke PillingOctober 22, 2026 41 min★ ★ ★ ★ ☆ 4/5HemochromatosisMultimorbidityPharmacogenetics
Life & Natural Systems Medicine & HealthENEP 262: The genetic drivers of hemochromatosis, drug response, and multimorbidity with Luke Pilli...Sano Genetics (Patrick Short)October 22, 2026 38 min★ ★ ★ ★ ☆ 4/5Genetic EpidemiologyHemochromatosisMultimorbidity
Formal & Physical Sciences AI — News & ApplicationsENEP 261: Inside the virtual biotech staffed by AI agents with James Zou of Stanford UniversitySano GeneticsOctober 15, 2026 36 min★ ★ ★ ★ ☆ 4/5AI AgentsVirtual BiotechDrug Discovery
Formal & Physical Sciences AI — News & ApplicationsENEP 261: Inside the virtual biotech staffed by AI agents with James Zou of Stanford UniversityJames ZouOctober 15, 2026 38 min★ ★ ★ ★ ★ 5/5AI AgentsDrug DiscoveryVirtual Biotech
Life & Natural Systems AI — News & ApplicationsENEP 260: How AI is reshaping genomics, disease prediction, and biosecurity with Jeffrey Barrett of...Sano GeneticsOctober 8, 2026 45 min★ ★ ★ ★ ☆ 4/5AIGenomicsFederated Learning
Life & Natural Systems BiologyENEP 260: How AI is reshaping genomics, disease prediction, and biosecurity with Jeffrey BarrettPatrick Short & Dr. Jeffrey BarrettOctober 8, 2026 48 min★ ★ ★ ★ ☆ 4/5AI in HealthcareGenomicsBiobank
Life & Natural Systems Medicine & HealthENEP 259: The patient community driving awareness & research for Danon disease with Jenny HsiehSano GeneticsOctober 1, 2026 40 min★ ★ ★ ★ ☆ 4/5Danon DiseaseRare DiseasePatient Advocacy
Life & Natural Systems Medicine & HealthENEP 258: The mutations hiding in healthy tissues with Inigo Martincorena of Wellcome Sanger InstituteSano GeneticsSeptember 24, 2026 42 min★ ★ ★ ★ ☆ 4/5Somatic MutationsCancerAutoimmune Disease
Humanities, Social Sciences & Thought Medicine & HealthENEP 257: Managing hereditary cancer risk and medical uncertainty with Marleah Dean KruzelSano GeneticsSeptember 17, 2026 42 min★ ★ ★ ★ ☆ 4/5GeneticsCancer RiskUncertainty
Life & Natural Systems AI — News & ApplicationsENEP 256: Cutting through the AI hype in drug discovery with Dave Hallett of RecursionSano GeneticsSeptember 10, 2026 45 min★ ★ ★ ★ ☆ 4/5AI in Drug DiscoveryClinical TrialsPhenotypic Screening
Life & Natural Systems Medicine & HealthENEP 255: Turning long-read sequencing into a routine part of clinical care with Danny MillerSano GeneticsSeptember 3, 2026 39 min★ ★ ★ ★ ☆ 4/5Long-Read SequencingClinical GeneticsStructural Variants
Life & Natural Systems Medicine & HealthENEP254:Triangulating genetic evidence & dodging bias to pick winning drug targets with Brent RichardsPatrick Short (host) with Dr. Brent RichardsAugust 27, 2026 43 min★ ★ ★ ★ ☆ 4/5GeneticsDrug DiscoveryMendelian Randomization
Life & Natural Systems ChemistryENEP 254: Triangulating genetic evidence and dodging bias to pick winning drug targets with Brent R...Sano GeneticsAugust 27, 2026 41 min★ ★ ★ ★ ☆ 4/5GeneticsDrug DiscoveryMendelian Randomization
Life & Natural Systems BiologyENEP 253: The genetics of brain size, growth, and aging with Andrew Jackson of the University of Ed...Patrick Short (host), Dr. Andrew Jackson (guest)August 20, 2026 37 min★ ★ ★ ★ ☆ 4/5GeneticsBrain SizeAging
Life & Natural Systems NeuroscienceENEP 253: The genetics of brain size, growth, and aging with Andrew JacksonPatrick Short (host), with guest Andrew JacksonAugust 20, 2026 41 min★ ★ ★ ★ ☆ 4/5GeneticsBrain SizeAging
Applied Sciences & Engineering Medicine & HealthENEP 252: The diagnosis that became a mission to cure rare disease with Stevie Ringel of NomePatrick ShortAugust 13, 2026 40 min★ ★ ★ ★ ☆ 4/5Rare DiseaseGene TherapyAI in Drug Development
Applied Sciences & Engineering Medicine & HealthENEP 251: Cracking the delivery barrier in genetic medicine with Jagesh Shah of Mirai BioPatrick ShortAugust 7, 2026 40 min★ ★ ★ ★ ☆ 4/5Gene TherapyLipid NanoparticlesDrug Delivery
Life & Natural Systems Medicine & HealthENEP 250: Redefining rare disease realities with Sharon Terry of the Genetic Alliance [Re-run]Sano GeneticsJuly 30, 2026 43 min★ ★ ★ ★ ☆ 4/5Rare DiseasePatient AdvocacyGenetic Testing
Life & Natural Systems Medicine & HealthENEP 250: Redefining rare disease realities with Sharon Terry of the Genetic Alliance [Re-run]Sharon TerryJuly 30, 2026 41 min★ ★ ★ ★ ☆ 4/5Rare DiseasePatient AdvocacyGenetic Testing
Life & Natural Systems Medicine & HealthENEP 249: Building the world's most detailed genetic map of inflammatory bowel disease with Carl An...Carl AndersonJuly 23, 2026 41 min★ ★ ★ ★ ★ 5/5IBDGeneticsSingle-Cell
Life & Natural Systems Medicine & HealthENEP 249: Building a genetic map of inflammatory bowel disease with Carl AndersonPatrick ShortJuly 23, 2026 44 min★ ★ ★ ★ ☆ 4/5IBDGeneticsSingle-Cell
Life & Natural Systems Medicine & HealthENEP 248: The blood mutations rewriting cardiovascular risk with Pradeep NatarajanSano GeneticsJuly 16, 2026 50 min★ ★ ★ ★ ☆ 4/5Clonal HematopoiesisCardiovascular GeneticsPolygenic Risk Scores
Life & Natural Systems NeuroscienceENEP 247: Why neurons accumulate mutations like clockwork: Somatic mosaicism and neurodegeneration ...Patrick ShortJuly 9, 2026 37 min★ ★ ★ ★ ☆ 4/5Somatic MosaicismNeurodegenerationAlzheimer's Disease
Life & Natural Systems NeuroscienceENEP 247: Why neurons accumulate mutations like clockwork with Christopher Walsh of Boston Children'sChristopher A. WalshJuly 9, 2026 41 min★ ★ ★ ★ ★ 5/5Somatic MosaicismNeurodegenerationAlzheimer's Disease
Life & Natural Systems Medicine & HealthENEP 246: Turning a fatal diagnosis into a cure strategy with Yentli Soto Albrecht of CureC9Yentli Soto AlbrechtJuly 2, 2026 36 min★ ★ ★ ★ ☆ 4/5C9orf72ALSFTD
Life & Natural Systems Medicine & HealthENEP 245: Developing targeted therapies for ALS with Eric Green of Trace Neuroscience [Re-run]Sano GeneticsJune 25, 2026 45 min★ ★ ★ ★ ☆ 4/5ALSGene TherapyUNC13A
Life & Natural Systems Medicine & HealthENEP 244: Building the first n-of-1 ASO: The new frontier of rare disease with Timothy Yu of Boston...Timothy YuJune 19, 2026 44 min★ ★ ★ ★ ☆ 4/5Rare DiseaseAntisense OligonucleotideN-of-1
Life & Natural Systems Medicine & HealthENEP 244: Building the first n-of-1 ASO with Timothy Yu of Boston Children’s HospitalSano GeneticsJune 18, 2026 49 min★ ★ ★ ★ ☆ 4/5N-of-1ASORare Disease
Life & Natural Systems Medicine & HealthENEP 243: How BD² is using genetics and deep phenotyping to transform bipolar researchSano GeneticsJune 11, 2026 48 min★ ★ ★ ★ ☆ 4/5Bipolar DisorderGeneticsDeep Phenotyping
Life & Natural Systems Medicine & HealthENEP 242: Connecting dementia research, policy, and patient communities with Angela Bradshaw [Re-Run]Patrick ShortJune 4, 2026 45 min★ ★ ★ ★ ☆ 4/5DementiaAlzheimer's DiseaseBiomarkers
Life & Natural Systems Medicine & HealthENEP 241: The hard-won lessons behind Encoded Therapeutics’ Dravet syndrome gene therapy [Re-run]Sano GeneticsMay 28, 2026 45 min★ ★ ★ ★ ☆ 4/5Gene TherapyDravet SyndromeClinical Trials
Life & Natural Systems Medicine & HealthENEP 240: Hijacking DNA repair machinery to treat Huntington’s disease with Vincent Dion of the UKDRIVincent DionMay 21, 2026 47 min★ ★ ★ ★ ☆ 4/5Huntington's DiseaseDNA RepairCRISPR
Life & Natural Systems Medicine & HealthENEP 239: What long-read sequencing reveals about Alzheimer’s and ALS with Paul ValdmanisSano GeneticsMay 14, 2026 44 min★ ★ ★ ★ ☆ 4/5Long-Read SequencingAlzheimer's DiseaseALS
Life & Natural Systems BiologyENEP 238: Uncovering epistatic interactions in complex disease with machine learning with Bin Yu of...Bin YuMay 7, 2026 39 min★ ★ ★ ★ ☆ 4/5EpistasisMachine LearningGenetics
Life & Natural Systems BiologyENEP 238: Uncovering epistatic interactions in complex disease with machine learning with Bin YuSano GeneticsMay 7, 2026 41 min★ ★ ★ ★ ☆ 4/5EpistasisMachine LearningRandom Forests
Life & Natural Systems Medicine & HealthENEP 237: How genetics and environment shape neurodegeneration with Sarah MarziSano GeneticsApril 30, 2026 42 min★ ★ ★ ★ ☆ 4/5NeurodegenerationGeneticsEnvironment
Humanities, Social Sciences & Thought Medicine & HealthENEP 236: Fixing access and design in rare disease drug development with experts and patient advocatesSano GeneticsApril 23, 2026 46 min★ ★ ★ ★ ☆ 4/5Rare DiseaseGene TherapyPatient Advocacy
Life & Natural Systems Medicine & HealthENEP 235: Inside Alzheimer’s disease: Blood biomarkers and predicting symptoms with Suzanne SchindlerSano GeneticsApril 16, 2026 43 min★ ★ ★ ★ ☆ 4/5Alzheimer's DiseaseBlood BiomarkersP-Tau217
![EP 250: Redefining rare disease realities with Sharon Terry of the Genetic Alliance [Re-run]](https://i.ytimg.com/vi/hO8tyZo0264/maxresdefault.jpg)
![EP 250: Redefining rare disease realities with Sharon Terry of the Genetic Alliance [Re-run]](https://i.ytimg.com/vi/_XJGMWDNoyk/maxresdefault.jpg)
![EP 245: Developing targeted therapies for ALS with Eric Green of Trace Neuroscience [Re-run]](https://i.ytimg.com/vi/bzuFMvk5KY0/maxresdefault.jpg)
![EP 242: Connecting dementia research, policy, and patient communities with Angela Bradshaw [Re-Run]](https://i.ytimg.com/vi/P8BhXlabgis/maxresdefault.jpg)
![EP 241: The hard-won lessons behind Encoded Therapeutics’ Dravet syndrome gene therapy [Re-run]](https://i.ytimg.com/vi/goY_S5vHQD4/maxresdefault.jpg)
